Best Fictional Drug Movies & TV Shows

At Deep Space Nine, a space station located next to a wormhole in the vicinity of the liberated planet of Bajor, Commander Sisko and crew welcome alien visitors, root out evildoers and solve all types of unexpected problems that come their way.

Paul Atreides, a brilliant and gifted young man born into a great destiny beyond his understanding, must travel to the most dangerous planet in the universe to ensure the future of his family and his people. As malevolent forces explode into conflict over the planet's exclusive supply of the most precious resource in existence-a commodity capable of unlocking humanity's greatest potential-only those who can conquer their fear will survive.

Two out-of-work actors -- the anxious, luckless Marwood and his acerbic, alcoholic friend, Withnail -- spend their days drifting between their squalid flat, the unemployment office and the pub. When they take a holiday "by mistake" at the country house of Withnail's flamboyantly gay uncle, Monty, they encounter the unpleasant side of the English countryside: tedium, terrifying locals and torrential rain.

Brian Finch's life takes an extraordinary turn when he uses NZT-48, a neuroenhancing drug whose mystery and chaos lead him to working for the FBI and a senator who is not what he seems.

As the president of a trashy TV channel, Max Renn is desperate for new programming to attract viewers. When he happens upon "Videodrome," a TV show dedicated to gratuitous torture and punishment, Max sees a potential hit and broadcasts the show on his channel. However, after his girlfriend auditions for the show and never returns, Max investigates the truth behind Videodrome and discovers that the graphic violence may not be as fake as he thought.

A highly intelligent chimpanzee named Caesar has been living a peaceful suburban life ever since he was born. But when he gets taken to a cruel primate facility, Caesar decides to revolt against those who have harmed him.

4400 centers on the return of 4400 people who, previously presumed dead or reported missing, reappear on Earth. Though they have not aged physically, some of them seem to have deeper alterations ranging from superhuman strength to an unexplained healing touch. A government agency is formed to track the 4400 people after one of them commits a murder.

A paranoia-fueled action thriller about an unsuccessful writer whose life is transformed by a top-secret "smart drug" that allows him to use 100% of his brain and become a perfect version of himself. His enhanced abilities soon attract shadowy forces that threaten his new life in this darkly comic and provocative film.

Martin Blank is a hitman for hire. When he starts to develop a conscience, he botches a couple of routine jobs. On the advice of his secretary and his psychiatrist, he decides to attend his ten-year high school reunion in Grosse Pointe, Michigan.

An undercover cop in a not-too-distant future becomes involved with a dangerous new drug and begins to lose his own identity as a result.

After a man with extraordinary—and frighteningly destructive—telepathic abilities is nabbed by agents from a mysterious rogue corporation, he discovers he is far from the only possessor of such strange powers, and that some of the other “scanners” have their minds set on world domination, while others are trying to stop them.

Mere seconds before the Earth is to be demolished by an alien construction crew, Arthur Dent is swept off the planet by his friend Ford Prefect, a researcher penning a new edition of "The Hitchhiker's Guide to the Galaxy."

In a utopia whose perfection hinges upon control of monogamy and privacy, members of the collective begin to question the rules, putting their regimented society on a collision course with forbidden love and revolution.

A white blood cell policeman, with the help of a cold pill, must stop a deadly virus from destroying the human they live in, Frank.

When two married business executives having an affair are blackmailed by a violent criminal, they are forced to turn the tables on him to save their families.

A new drug promises out-of-body experiences, but users are coming back changed forever, and an otherworldly invasion of Earth is underway.

Frederick Fitzell is living his best life—until he starts having horrific visions of Cindy, a girl who vanished in high school. After reaching out to old friends with whom he used to take a mystery drug called Mercury, Fredrick realizes the only way to stop the visions lies deep within his own memories, so he embarks on a terrifying mental odyssey to learn the truth.

After taking a new form of ecstasy, a psychopath goes through a mind bending trip causing him to feel and question his morality for the first time.

By the year 2056, an epidemic of organ failures has devastated the planet. The megacorporation GeneCo provides organ transplants on a payment plan - and those who can’t fulfill their plans have their organs repossessed. In the midst of this, a sickly teenager discovers a shocking secret about herself, her father, and their connection to GeneCo.

A student gets his senses enhanced by an experimental drug. But abuse is not an option.

An American master chemist plans to score big on a once in a lifetime drug deal. All does not go as planned and he is soon entangled in a web of deceit.

A dangerous international spy is determined to give up his high stakes life to finally build a closer relationship with his estranged wife and daughter. But first, he must complete one last mission - even if it means juggling the two toughest assignments yet: hunting down the world's most ruthless terrorist and looking after his teenage daughter for the first time in ten years, while his wife is out of town.

A few years from now, Earth will have the first contact with an alien civilization. These aliens, known as Newcomers, slowly begin to be integrated into human society after years of quarantine.

Perennially stoned Cheech and Chong tear through the city of Los Angeles, causing trouble wherever they go. After Cheech loses his job, the two pot enthusiasts head to the welfare offices where Cheech's girlfriend, Donna, works. Instead of collecting unemployment, they find themselves thrown back on the streets, searching for a way to earn new income. But when Cheech's cousin, "Red" Mendoza, arrives, things get even crazier.

The time is in the future and the youth gang violence is so high that the areas around some schools have become "free-fire zones", into which not even the police will venture. When Miles Langford, the head of Kennedy High School, decides to take his school back from the gangs, robotics specialist Dr. Robert Forrest provides "tactical education units". These are amazingly human-like androids that have been programmed to teach and are supplied with devastatingly effective solutions to discipline problems. So when the violent, out-of-control students of Kennedy High report for class tomorrow, they're going to get a real education... in staying alive!

A man who grew up in a primitive society educating himself by reading Shakespeare is allowed to join the futuristic society where his parents are from. However, he cannot adapt to their repressive ways.

A prisoner in a state-of-the-art penitentiary begins to question the purpose of the emotion-controlling drugs he's testing for a pharmaceutical genius.

An alien creature invades New York's punk subculture in its search for an opiate released by the brain during an orgasm.

In a world where human beings and puppets live together, when the members of the cast of a children's television show aired during the 1990s begin to get murdered one by one, puppet Phil Philips, a former LAPD detective who fell in disgrace and turned into a private eye, takes on the case at the request of his old boss in order to assist detective Edwards, who was his partner in the past.

In a futuristic totalitarian utopian society, babies are created through genetic engineering, everyone has a predestined place in society and their minds are conditioned to follow the rules. A tragic outsider jeopardizes the status quo.

400 years into the future, disease has wiped out the majority of the world's population, except one walled city, Bregna, ruled by a congress of scientists. When Æon Flux, the top operative in the underground 'Monican' rebellion, is sent on a mission to kill a government leader, she uncovers a world of secrets.

Seattle medical examiner David Krane is obsessed with solving his wife's murder. A possible solution presents itself in an experimental "memory" serum designed by a neurobiology professor, which has the ability to transfer memories from one person to another, but with potentially fatal consequences.

After four years, Jake Cardigan is prematurely awoken from his fifteen year cryogenic punishment to a world very different than the one he knew. Much more than before 'Tek', the highly-addictive electronic designer narcotic of the 21st century, seems to be prevalent. His wife has divorced him and disappeared together with their son. He wants them back and he wants justice for those undercover policemen who were murdered by unknown conspirators which led to his imprisonment for a crime he did not commit.

In the Los Angeles of the future, police are forbidden to carry weapons and must use stun guns instead. A maverick detective ignores those restrictions in his pursuit of "The Bullseye Murderer," a psychotic rapist who takes a new drug called "Umbra" that gives him superhuman strength and intelligence.

Christopher Lee stars in this Amicus production of “Dr. Jekyll & Mr. Hyde” where the names have been changed to Dr. Marlowe and Mr. Blake. Lee as Dr. Marlowe experiments with intravenous drugs that are suppose to release inner inhibitions. So comes forth Mr. Blake (also Lee) who gets more monstrous with each transformation. Peter Cushing plays his friend and colleague, Dr. Utterson.

After Ashe and his little son are murdered violently for no reason by Judah's men, he returns from the dead to take revenge. One after one, Judah's people face the power of the dark angel. The second film based on James O'Barr's cult comic.

TekWar is a North American television series, based on the TekWar novels ghost-written by Ron Goulart from outlines by William Shatner and developed for television by Stephen Roloff. The series follows Jake Cardigan, a former police officer turned private investigator working for Cosmos, a private security firm owned and operated by Walter Bascom. The series was broadcast in Canada on CTV and in the United States on USA Network and the Sci Fi Channel. The series, which was a co-production between Atlantis Films and Universal Television premiered on January 17, 1994 and ended on February 9, 1996.

When a group of college students take part in a clinical drug trial, an unexpected side effect of the experimental medicine gives them terrifying visions of their own deaths...which begin to come true. As they scramble to escape their fate, they discover that the killer is among them and shares their ability to see the future - only he seems to be one step ahead of their efforts to survive.

A man afflicted with clairvoyance tries to change his fate when a series of events leads to a vision of his own imminent murder.

After he's institutionalized in order to cover for his sister, a young man encounters a doctor who is turning his patients into flesh-eating psychopaths

With a spate of violence that rocks the inner city, L.A.P.D. and ex-Marine John Kross investigates its cause: a new drug called Chaos. With help from his partner Carpenter, they delve into the mystery, only to discover a link between the drug and a terrifying supernatural power unleashed during the gulf war, witnessed by Kross twelve years ago. Now, Kross must race against time to stop the destruction, battle his own demons and come to grips with his destiny as he discovers that his reality has been mapped by a power much greater than himself.

The "Coldfire" is a lethal new designer-drug with destructive capabilities. Its origins are unknown...and its effects are irreversible. This drug promises the "ultimate high." However, what does the user acquire instead? The ultimate way to die... The main purpose of the "Coldfire" drug is to help the enemy cripple the United States. An epidemic is imminent if the use of this drug spreads everywhere... Entering the scene are Nick and Jake Edwards two audacious police officers. They may lack age, but they certainly have attitude. These Generation-X cops hope to show some of the veteran members of the police force a trick or to. These two officers will be working with a company of experienced pros including the seasoned Lars and the short-tempered Dix. Their assignment is to track down who or what is responsible for the distribution of this virulent drug substance... Written by David Choi

The story follows the adventures of Aang, a young successor to a long line of Avatars, who must put his childhood ways aside and stop the Fire Nation from enslaving the Water, Earth and Air nations.

A young female scanner turns from a sweet young thing into a murderous, power-crazed villain after she takes an experimental drug developed by her father. Her brother, who is also a scanner, is the only one powerful enough to stop her.

When Sawa's mother and policeman father are found victims of a grisly double homicide, she begins a ruthless pursuit for the man who murdered them. With the help of her father's ex-partner, Karl Aker, and a mysterious friend from her past, she becomes a merciless teen assassin, blasting her way through the dark world of human trafficking only to uncover a devastating truth

A renegade federal agent uses a new drug to create an army of unbeatable warriors.

Brian's mother dies and is surprised when he inherit's The Sanctuary, her controversial experimental treatment center for addictions. When he and his friends are shown around the dilapidated building by a mysterious employee, it is clear that there is a sinister mood. Despite this the group enters a secret underground passage and the terrible reality is revealed. Brian's mother had built a revolutionary machine that cured people of their addiction, but as a side effect to materialize the addictions in a mutated form of children who are addicted to human flesh which have moved into the building.

Having suffered with psychosis for twenty years, Eddie is on advanced trials for a new drug called Ceresia. Near FDA approval, his progress breaks down as a new romance begins to invoke memories of his mother's fatal accident.

When Dr Lauren Anderson agrees to Thomas Mordley testing his experimental new drug Cyberon on her brain damaged patients she expects little benefit. But Cyberon is going to revolutionize medicine and maybe even the world.