Top 250 Movies Like Chromosome 21

The story begins in 1923 where after an accident, a newspaper reporter needs to raise $5,000 to pay for an operation, otherwise his young sister will be crippled for life. The desperate reporter is finally able to get the cash from a shady acquaintance, Riggs. Eight years later in New York, circumstances conspire to place the reporter as the number one suspect in the murder of a showgirl. With no witness or alibi, the reporter devises a plan to smoke out the real culprit. A meeting is arranged under the cover of night and to the surprise of both men, the murderer is Riggs. Out of gratitude for past generosity to his sister, the reporter agrees not to expose Riggs, however unwittingly leads the police to him! Riggs is found guilty, and a dramatic scene in the courthouse ensues.

A private detective, soon to enlist in the army, is drawn into one final case when his police officer father is killed in the line of duty. Soon his prime suspect is murdered as well, and he finds himself framed for the crime. As more witnesses get murdered, he finds himself on the run from both the police and former Prohibition violators who seem to have found a new racket.

Private eye Edward Mercer travels to Venice to locate a man due a reward for his aid in the war. Shortly after arriving, he becomes the prime suspect in the murder of his local contact. In his quest to clear his name, Mercer uncovers a conspiracy. Even the local magistrate seems to be working against him, and Mercer begins to suspect the man he came to find is behind it all.

After an innocent man is executed in a case he was responsible for, a Scotland Yard superintendent finds himself investigating the murder of his key witness.

A man's nervous breakdown causes him to leave his wife and live in his attic for several months.

A sheltered Amish child is the sole witness of a brutal murder in a restroom at a Philadelphia train station, and he must be protected. The assignment falls to a taciturn detective who goes undercover in a Pennsylvania Dutch community. On the farm, he slowly assimilates despite his urban grit and forges a romantic bond with the child's beautiful mother.

John Cummings, an unsuccessful cosmetics salesman, has his unpaid-for car stolen by one of the hoods in the employ of Lionel Meadows, the sadistic organizer of a London car conversion racket. The car was not insured, and since the police appear indifferent to his plight, Cummings decides to find it himself -- and gets himself involved in an underworld battle.

A law student takes a job as a night watchman at a morgue and begins to discover clues that implicate him as the suspect in a series of murders.

A veteran high school teacher befriends a younger art teacher, who is having an affair with one of her 15-year-old students. However, her intentions with this new "friend" also go well beyond platonic friendship.

The stooges witness an armed robbery and are brought in by the cops as suspects. After passing a lie detector test, the boys are freed and go back to their jobs in a Cafe. When one of the robbers comes into the Cafe, the boys recognize him and along with their friend Gladys trail him to a spooky house in the country where the crooks are hiding out. The bad guys abduct Gladys and the stooges must rescue her.

College student Jake Lo is pursued by smugglers, mobsters and crooked federal agents after he witnesses a murder by a Mafia kingpin.

When up-and-coming District Attorney Mitch Brockden commits a fatal hit-and-run, he feels compelled to throw the case against the accused criminal who was found with the body and blamed for the crime. Following the trial, Mitch's worst fears come true when he realizes that he acquitted a guilty man, and he soon finds himself on the hunt for the killer before more victims pile up.

In the gold fields of the Canadian Northwest, a man is falsely accused of a crime and determines that a lookalike is responsible.

A Down-syndrome boy left in an institute by his parents. Ginny works in the institute and wants to have Jonathan but has to fight the system and the parents.

A man takes over the identity of a dead man while on the lam from a crime he didn't commit.

Chris and Bill are called upon for their excellent surveillance record to stakeout a lakeside home where a Mafia trial witness is believed to be heading or already hiding.

In a quiet Connecticut town, a kindly priest is murdered while waiting at a street corner. The citizens are horrified and demand action from the police. All of the witnesses identify John Waldron, a nervous out-of-towner, as the killer. Although Waldron vehemently denies the crime, no one will believe him. District Attorney Henry Harvey is then put on the case and faces political opposition in his attempt to prove Waldron's innocence. Based on a true story.

In the 1970s, a foundling lass, Patrick "Kitten" Braden, comes of age by leaving her Irish town for London, in part to look for her mother and in part because her transgender nature is beyond the town's understanding.

Bernice "Bernie" Rhodenbarr is a burglar by trade, and she runs a bookstore as well. Her friend Carl Hefler is a dog groomer. After a successful burglary, it's discovered that a dead body was in the house she burgled. As she's the only one who can be placed at the scene of the crime, she has to use her criminal skills to clear her name of the murder AND avoid getting charged with the burglary.

Single mother Sarah Palmer hides her family in Oregon when her daughter Christy becomes a key witness in a murder against the mob.

A novelist moves to a small town to write her next novel. She seeks inspiration and as time goes by she gathers information about her neighbor, a young, wealthy man whom she observes, as well as photographs, from her window. She soon finds herself a suspect in a murder investigation due to suspicious circumstances involving her odd behavior and reclusive lifestyle. She must fight to demonstrate her innocence.

Lacey Smithsonian is a stylish journalist who works as a television reporter. When interviewing a prestigious fashion designer Amanda Manville, it confesses that receives death threats from someone. Everything is complicated when the artist is shot dead during the program. Lacey will be involved in the case and launch an investigation to find the guilty.

During a blizzard in 1964, Dr. David Henry delivers his son Paul with the help of nurse Caroline. But when Henry realizes his wife is also carrying a girl with Down syndrome, he hands the second child over to Caroline without his wife's knowledge. Henry's fateful decision yields grave consequences for his family over the next 20 years.

Dr. Matthew Clark is the head of a state institution for intellectually disabled children. Jean Hansen, a former music teacher anxious to give her life some meaning, joins the staff of the hospital. Jean, who tries to shelter the children with her love, suspiciously regards Dr. Clark's stern training methods. She becomes emotionally involved with 12-year-old Reuben Widdicombe, who has been abandoned by his divorced parents.

Will is a 30-something website manager who uses local café, Coffee Town, as his office. When the owners of the shop discuss plans to convert Coffee Town into a bar, Will enlists the help of his two best friends Chad and Gino to save his freeloading existence. In order to thwart the plans of Coffee Town's owners, the trio stages a robbery to create the illusion of an unsafe neighborhood not suitable for the proposed venue. Also standing in their way is Sam, a disgruntled barista with delusions of grandeur and Will's heartache over unrequited love for Becca.

An ex-military accountant is recruited by the FBI to infiltrate the mob in Chicago in an attempt to break open the rackets. To complicate his job, two women stand in his way, each with their own agenda.

A man is murdered, apparently by one of a group of soldiers just out of the army. But which one? And why?

A police chief tries to solve a kidnapping that involves a bank robber holding a young boy hostage.

London. A mysterious serial killer brutally murders young blond women by stalking them in the night fog. One foggy, sinister night, a young man who claims his name is Jonathan Drew arrives at the guest house run by the Bunting family and rents a room.

When his best friend is murdered inside a London dancehall, a cab driver and his girlfriend involve themselves in the investigation and discover a major criminal operation hiding behind the club's friendly facade.

In Tiger Bay, the docklands of Cardiff, rough-and-tumble street urchin Gillie witnesses the brutal killing of a young woman at the hands of visiting Polish sailor Korchinsky. Instead of reporting the crime to the authorities, Gillie merely pockets a prize for herself — Korchinsky's shiny black revolver — and flees the scene. When Detective Graham discovers that Gillie has the murder weapon, the fiery young girl weaves a web of lies to throw him off course.

A forensic psychologist must determine if a minor should be charged with murder.

NYC custodian Daryll Deever is a big fan of local news reporter Tony Sokolow, so he is intrigued when she shows up to cover a story at his workplace. There's been a murder in the office building, and Tony suspects that Daryll may have insight into the crime, a notion that he furthers to stay close to her. However, when those behind the killing begin to think that he really knows something, they target the pair to keep their secrets hidden.

A young man with Down's Syndrome romantically pursues a small town single mom who is still mixed up with her volatile ex-boyfriend.

A young Los Angeles police officer and a mysterious gnome become unlikely partners as they track a killer. When a sting operation goes awry, officer Casey is blamed for the murder of his colleague and Gnorm the gnome is the only witness.

One of six travelers who catch the bus from Casablanca airport to Marrakesh is carrying $2 million to pay a local operator to fix United Nations votes. But which one?

An undercover officer tracks waterfront corruption from California to New Orleans and back.

Rembrandt Macy (Tom Berenger) is a maverick cop assigned to a case where the primary evidence is a woman's hand found in a pond. Investigators identify the dead, and Macy is lead into a young woman's past. Macy's primary path to understanding the victim is through one of her roommates, Nikki. Through Nikki and others, Macy learns of the victim's shady contacts at City Hall, the involvement of a gang of Asian drug runners, and the sordid affairs of one of the city's bigwigs. As Macy begins to understand how all these crimes fit together, he learns that his new friend Nikki is not an innocent bystander.

A crook on the run hides out in an innocent girl's apartment.

This film-noir piece, told in semi-documentary style, follows police on the hunt for a resourceful criminal who shoots and kills a cop.

An aspiring actress begins to suspect that her temperamental and mentally impaired boyfriend is a murderer.

A small-town police chief investigating a murder is offered help by a self-described psychic. However, when the chief discovers that the "psychic" is in possession of information known only to the police, he suspects that the man may be more involved in the case than he lets on.

Luke, an independent young man with Down's syndrome stumbles upon a wild and life changing friendship.

A down-on-his-luck crab fisherman embarks on a journey to get a young man with Down syndrome to a professional wrestling school in rural North Carolina and away from the retirement home where he’s lived for the past two and a half years.

Sarah Jo is a naive 26-year-old living on the fringes of Hollywood with her mother and sister. When she begins an affair with her older employer, she is thrust into an education on sexuality, loss and power.

Molly, the eldest child of a group of orphans being used as slaves on a farm hidden deep in a swamp, must rescue the others when their cruel master decides that one of them will be disposed of.

A man known to be a mute is suspected of committing a murder, as he was noticed at the scene. However, witnesses saw and heard him talking as he was leaving the scene of the crime. The police must determine if he is the actual killer or if he is being framed.

Two criminals chase a plainclothes policeman who, while taking out his dog, witnesses their crime.

In a town of low-income and fractured families, a group of teens are lured into working for a dangerous drug dealer. A new girl arrives who hides a dangerous secret that will impact everybody and change their lives forever.

Martin Durnley is a young man with an infantilizing mother, resentful stepfather and an institutionalized brother with Down's syndrome. To cope, he retreats into an alternate child personality he calls Georgie. After being caught during a theft attempt at a department store, he befriends a female customer who is sympathetic to him, but his friendship soon turns into obsession.

A drug deal hijacked by a third party, they leave the drugs and take the money. A stripper witnesses a murder and now the Mafia's after but there is nowhere safe to hide.

A single mother is overprotective of her mentally challenged son, which has made him angry and difficult, while she denies herself a social life. Things change for the better when the boy gains self-esteem training for the Special Olympics, and his mother learns to let go.

A hootchy-kootchy whodunit set at a small seedy carnival where a reporter tries to discover who killed his boss while his girlfriend inexplicably joins the burlesque show!

A pretty blonde with a Doberman pinscher walks into a bar on April Fool's Day and asks for a bag of bones. Thus begins a merry chase in which a newspaper reporter, a drunken policeman and a hand-painted necktie help locate the missing witness in a criminal investigation.

After being dismissed for imitating his boss's voice on radio, former Assistant District Attorney Richard Deming witnesses a store robbery and is taken captive by the criminals. Suspected of the crime, he is sought by the police, but his sweetheart, Marie, convinced of his innocence, enlists the help of two friends, a newspaper reporter and a half-witted detective. Hoping to win the girl's favor, the two go to the gangsters' hideout, encounter a violent gang war, and accidently set off a case of police tear bombs. The police, summoned by Marie, arrive just in time to save the kidnaped attorney.

Hotel night clerk Bart Bromley is a highly intelligent young man on the Autism spectrum. When a woman is murdered during his shift, Bart becomes the prime suspect. As the police investigation closes in, Bart makes a personal connection with a beautiful guest named Andrea, but soon realises he must stop the real murderer before she becomes the next victim.

Calvin Campbell is a former professional baseball player sent to an early retirement due to his panic attacks at the plate. Even though he had all the talent for the big leagues, he struggles with the curveballs life has thrown him. Today, he mindlessly sleepwalks through his days and the challenge of raising his teenager daughter. His life is in a slow downward spiral when it is suddenly awakened and invigorated by the most unlikely person – Produce, a young-man with Down syndrome who works at the local grocery store.

Sir Harry Oakes is a wealthy magnate, living amongst the British aristocrats who have made their home in the Bahamas just prior to World War II. Their small community is one of privilege and status and when Sir Harry's beloved daughter marries a handsome but penniless gigolo, Alfred De Marigny, Sir Harry is outraged by the union. But before Sir Harry can break up the marriage he is brutally and viciously murdered and his son-in-law is the prime suspect. Nothing is as it appears and Sir Harry's death soon points towards intrigue and deception on an international scale.

James Houghland, inventor of a new method by which television signals can be instantaneously sent anywhere in the world, refuses to sell the process to television companies, who then send agents to acquire the invention any way they can. On the night of his initial broadcast Houghland is mysteriously murdered in the middle of his demonstration and it falls to Police Chief Nelson to determine who the murderer is from the many suspects present.

Cock Robin is the swaggering ballyhoo man of a Hungarian sideshow known as the Palace of Illusions. The highlight of the show is a reenactment of Salome's dance of the seven veils, replete with the beheading of Jokanaan. The performer portraying Salome is in love with Cock Robin. Jealous, sinister The Greek is determined to eliminate that competition.

Wealthy scion Peter DeHaven, about to marry socialite Christine Lunceford, wakes up after bachelor party revelry to find he's been turned invisible by eccentric college professor Reginald Shotesbury. An unbelievable series of events is revealed by several witnesses testifying in a "mystery trial" to determine the reason for DeHaven's "disappearance".

In this mystery, a newspaper executive and three of his colleagues conspire to have the owner of the highly-respected London Sun committed to an insane asylum. The hapless publisher manages to escape. Soon after, the four collaborators begin dying one-by-one. Oddly their obituaries appear in a rival publication before they are actually killed.

A girl reporter is trying to tack down the lady-in-the-title, as a key witness in a graft trial, which involves three murder and that many failed attempts. A prosecuting attorney in the district attorneys office is aiding her in solving the mystery of the missing lady.

A man having marital problems with his shrewish wife picks up a young, pretty and pregnant hitchhiker. Before he knows it, he's in over his head and mixed up in violence and murder.

The Senior Prank is family drama about a group of popular teenagers who wage a fake campaign to elect a girl with Down Syndrome as the schools Homecoming Queen. Inspired by real bullying events witnessed by real teenagers in their local high schools.

An escaped convict and a woman ponder what to do with a not-quite-dead body.

A newspaper reporter keeps beating the police to clues in a current murder case. This makes the police think he may be involved in the crime.

Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.

Martha and Jed Richards live in Oregon in 1862. They and their two daughters moved there to make a new life, but the daughters died of cholera along the way. This has left Martha an emotional wreck, and she is unable to move on with her life. That is until an orphan named Danny comes to live with them. Jed immediately accepts Danny as his son, but Martha is still too upset to be able to love him. As time passes, however, she finds herself more and more able to accept him as part of the family.

Renegade cops are videotaped murdering a motorist and the witnesses are in danger of being their next victims.

A tough District Attorney goes after a murderous crime gang, only to find that his witnesses, an innocent family, have clammed up in fear of reprisals.

A beautiful showgirl, name "the Canary" is a scheming nightclub singer. Blackmailing is her game and with that she ends up dead. But who killed "the Canary". All the suspects knew and were used by her and everyone had a motive to see her dead. The only witness to the crime has also been 'rubbed out'. Only one man, the keen, fascinating, debonair detective Philo Vance, would be able to figure out who is the killer. Written by Tony Fontana

Accused of killing her employer, financier Bjorn Faulkner, Kit is championed by wisecracking sailor-on-leave Steve Van Ruyle, who has a vested interest in the outcome of the trial.

Scotland Yard is thrown into an uproar when a mad killer begins knocking off beautiful young blondes.

Like the first entry, this one is played mostly for laughs, with Radio's Mister District Attorney. James Ellison replacing Dennis O'Keefe as feckless assistant DA P. Cadwallader Jones. The publisher of a tony fashion magazine is murdered, requiring Jones to sift through a colorful array of suspects. He is helped along by snoopy girl reporter Terry Parker.

There's something very odd about Romano, a notorious gangster serving time in the federal pen. For one thing, Romano doesn't sound much like himself. For another, he always seems to be hiding something. Detective Lee suspects that something's amiss, and he's probably right!

A detective and his bumbling sidekick join the crackdown on racketeering in '30s New York City.

A town busybody is poisoned at a busy reception in the home of famous film star Marina Gregg. The poisoned drink seemed intended for Marina, but Miss Marple is not so sure. She sets out to discover the true identity of the killer before he or she can strike again.

An ugly girl undergoes plastic surgery and becomes beautiful. She then takes revenge on all the people who mistreated her when she was ugly.

A blind professor is accused by the police of killing his neighbor and must clear his name by finding the murderer.

A female lawyer who specialises in defending suspected rapists is left traumatised after she herself is assaulted in her own home.

Two San Francisco detectives investigating a murder committed on one of the city's famous cable cars discover that the victim was the son of a shipping tycoon. The trail leads to a drug dealer, a shady physician and a nervous police captain

Run-D.M.C. DJ Jam Master Jay made a huge impact in music and his community. But friends and family still seek closure years after his unsolved murder.

A veteran street cop and his partner, a robot programmed to be the perfect policeman, are assigned to protect the five-year-old daughter of the widow who witnessed the killing of her police officer husband and now is stalked by the gangster who murdered him.

A female photographer teams up with a policeman to try to bring down a corrupt police officer who framed her for drug possession and during her investigation, finds that not everything, or everyone, is what they appear to be.

Police detective Jack Flinder is already in trouble with the rest of his force for imprisoning a corrupt partner, but now he has a new problem to deal with. Another officer has been murdered in a hotel room, where he was with a prostitute named Lisa, who managed to escape with her life. Flinder has to track down Lisa to find out what happened, but the answer proves the corruption in his department runs much deeper than he had initially believed.

1890, London, and a serial killer known as The Terror is murdering policemen. When gentleman thief Nicholas Revel unwittingly becomes the chief suspect, he must use his guile and wits to prove he’s not the killer; whilst also not getting caught for a jewel robbery he has just committed.

A schoolteacher and amateur sleuth suspects foul play when a fellow passenger on a seaplane gets sick and dies. The third and final film with Edna May Oliver and James Gleason as the astute schoolteacher Hildegarde Withers and the New York Police Inspector Oscar Piper busy solving crimes.

Homophobic detective Mark Rima must "partner" up with the very gay and flamboyant Detective Chris Riant to stop a serial killing Nun from offing 5 band members otherwise known as "The Ex Choir Boys." But when it is determined that the detectives can't solve the case on their own, expert F.B.I. profiler Agent Peccant (comedian Ant) is assigned to the case. As the details of the case slowly emerge the police determine that that the "nun" may only be a silent witness to the grisly murders. The task force then turns its attention on the Catholic Church and a suspect group of Priests that have had a propensity for "cleansing the souls" of innocent young choir boys.

A young girl falls in love with a member of a gang of crooks. She determines to bring the rest of the gang to justice so she can save the man she loves.

The 60s, London: The Krays are on the rise, using their inimitable violent ways to gain power over the city. One man, the fearless Detective Nipper Read, is sent in to tackle the unenviable task of bringing the city back under the rule of law and taking on the country's most feared mobsters in the process. As he faces bent coppers, political backstabbing, and terrified witnesses, Nipper becomes increasingly obsessed, putting everything and everyone he knows at risk.

A handsome, brilliant stock trader, bored with his existence, becomes a serial killer.

Neighborhood nice guy Diontay (Tay) Wilson is thrust into an uncomfortable situation after witnessing the murder of his estranged lover in his workplace, the neighborhood Coney Island Restaurant. Because of his tumultuous relationship with the deceased party, Diontay is considered a suspect by the police as well as the family of the deceased and commits all of his efforts to clear his name so he can pursue his dream of moving away to college all while under the watchful eye of the real killer.

A couple whose son had been institutionalized for three years are shocked to discover that the diagnosis was wrong, and that their son is, in fact, deaf.

An original drama by novelist Mark Haddon about two teenage brothers: angst-ridden David and Ben, who has Downs Syndrome.

Set in Brittany, a detective called Nicolas Luhel is asked to unravel the circumstances of a teenage boy's death. The main suspect is the boy's father. Shattered by the suicide of the main witness, Nicolas lets himself get snared by the strange and fascinating influence that the father exerts on everyone around him. Eventually, Luhel discovers the truth about the murder and feels that the law is inadequate to deal with it. As a consequence, he decides to destroy the evidence and keep it a secret.

Bob and Joanna, both over 40 years old, have a baby with the Down syndrome. Their doctor advises them to give the child away, not to "waste their time" with a kid with a mental deficiency. But the parents decide to keep their son, to allow him a life with dignity and to support him as best as possible. And their devotion bears fruit...

Two men being questioned in a police station on Christmas Eve both confess to the murder of a cop. With both stories seeming plausible, an investigator is called in to determine which suspect is telling the truth - and why the other one is lying. Crime drama, starring James Earl Jones and Jason Bateman.

A wealthy, cheating husband is found murdered in his penthouse apartment. The police soon arrest a suspect, but the victim's downstairs neighbor believes the man is innocent and sets out to prove who really committed the murder.

27 year old surgical resident, Kendal Lawrence is living and working in Brooklyn, New York. She is abducted, on route to meeting her same sex partner, Lauren Stevens and their mutual friend, female police officer, Maria Rossetti. The question of terrorism arises several times throughout the story, with an unexpected medical twist, to the plot. The FBI and the New York Police department work closely together, to determine the reason for the abduction. Sensing a lack of interest, on the part of the police authorities, because of her sexual orientation and her partner's Middle eastern heritage, Lauren decides to launch her own investigation. When you least expect it, your life can take a detour that may in fact, change your world forever.