Best movies & TV Shows like Chromosome 21

A veteran high school teacher befriends a younger art teacher, who is having an affair with one of her 15-year-old students. However, her intentions with this new "friend" also go well beyond platonic friendship.

The stooges witness an armed robbery and are brought in by the cops as suspects. After passing a lie detector test, the boys are freed and go back to their jobs in a Cafe. When one of the robbers comes into the Cafe, the boys recognize him and along with their friend Gladys trail him to a spooky house in the country where the crooks are hiding out. The bad guys abduct Gladys and the stooges must rescue her.

A Down-syndrome boy left in an institute by his parents. Ginny works in the institute and wants to have Jonathan but has to fight the system and the parents.

Bernice "Bernie" Rhodenbarr is a burglar by trade, and she runs a bookstore as well. Her friend Carl Hefler is a dog groomer. After a successful burglary, it's discovered that a dead body was in the house she burgled. As she's the only one who can be placed at the scene of the crime, she has to use her criminal skills to clear her name of the murder AND avoid getting charged with the burglary.

Will is a 30-something website manager who uses local café, Coffee Town, as his office. When the owners of the shop discuss plans to convert Coffee Town into a bar, Will enlists the help of his two best friends Chad and Gino to save his freeloading existence. In order to thwart the plans of Coffee Town's owners, the trio stages a robbery to create the illusion of an unsafe neighborhood not suitable for the proposed venue. Also standing in their way is Sam, a disgruntled barista with delusions of grandeur and Will's heartache over unrequited love for Becca.

A man is murdered, apparently by one of a group of soldiers just out of the army. But which one? And why?

A young man with Down's Syndrome romantically pursues a small town single mom who is still mixed up with her volatile ex-boyfriend.

A young Los Angeles police officer and a mysterious gnome become unlikely partners as they track a killer. When a sting operation goes awry, officer Casey is blamed for the murder of his colleague and Gnorm the gnome is the only witness.

An undercover officer tracks waterfront corruption from California to New Orleans and back.

A small-town police chief investigating a murder is offered help by a self-described psychic. However, when the chief discovers that the "psychic" is in possession of information known only to the police, he suspects that the man may be more involved in the case than he lets on.

Luke, an independent young man with Down's syndrome stumbles upon a wild and life changing friendship.

Sarah Jo is a naive 26-year-old living on the fringes of Hollywood with her mother and sister. When she begins an affair with her older employer, she is thrust into an education on sexuality, loss and power.

A man known to be a mute is suspected of committing a murder, as he was noticed at the scene. However, witnesses saw and heard him talking as he was leaving the scene of the crime. The police must determine if he is the actual killer or if he is being framed.

Calvin Campbell is a former professional baseball player sent to an early retirement due to his panic attacks at the plate. Even though he had all the talent for the big leagues, he struggles with the curveballs life has thrown him. Today, he mindlessly sleepwalks through his days and the challenge of raising his teenager daughter. His life is in a slow downward spiral when it is suddenly awakened and invigorated by the most unlikely person – Produce, a young-man with Down syndrome who works at the local grocery store.

In this mystery, a newspaper executive and three of his colleagues conspire to have the owner of the highly-respected London Sun committed to an insane asylum. The hapless publisher manages to escape. Soon after, the four collaborators begin dying one-by-one. Oddly their obituaries appear in a rival publication before they are actually killed.

A man having marital problems with his shrewish wife picks up a young, pretty and pregnant hitchhiker. Before he knows it, he's in over his head and mixed up in violence and murder.

The Senior Prank is family drama about a group of popular teenagers who wage a fake campaign to elect a girl with Down Syndrome as the schools Homecoming Queen. Inspired by real bullying events witnessed by real teenagers in their local high schools.

A newspaper reporter keeps beating the police to clues in a current murder case. This makes the police think he may be involved in the crime.

Frank Johnson, a sole witness to a gangland murder, goes into hiding and is trailed by Police Inspector Ferris, on the theory that Frank is trying to escape from possible retaliation. Frank's wife, Eleanor, suspects he is actually running away from their unsuccessful marriage. Aided by a newspaperman, Danny Leggett, Eleanor sets out to locate her husband. The killer is also looking for him, and keeps close tabs on Eleanor.

A beautiful showgirl, name "the Canary" is a scheming nightclub singer. Blackmailing is her game and with that she ends up dead. But who killed "the Canary". All the suspects knew and were used by her and everyone had a motive to see her dead. The only witness to the crime has also been 'rubbed out'. Only one man, the keen, fascinating, debonair detective Philo Vance, would be able to figure out who is the killer. Written by Tony Fontana

An ugly girl undergoes plastic surgery and becomes beautiful. She then takes revenge on all the people who mistreated her when she was ugly.

A veteran street cop and his partner, a robot programmed to be the perfect policeman, are assigned to protect the five-year-old daughter of the widow who witnessed the killing of her police officer husband and now is stalked by the gangster who murdered him.

Homophobic detective Mark Rima must "partner" up with the very gay and flamboyant Detective Chris Riant to stop a serial killing Nun from offing 5 band members otherwise known as "The Ex Choir Boys." But when it is determined that the detectives can't solve the case on their own, expert F.B.I. profiler Agent Peccant (comedian Ant) is assigned to the case. As the details of the case slowly emerge the police determine that that the "nun" may only be a silent witness to the grisly murders. The task force then turns its attention on the Catholic Church and a suspect group of Priests that have had a propensity for "cleansing the souls" of innocent young choir boys.

An original drama by novelist Mark Haddon about two teenage brothers: angst-ridden David and Ben, who has Downs Syndrome.

Bob and Joanna, both over 40 years old, have a baby with the Down syndrome. Their doctor advises them to give the child away, not to "waste their time" with a kid with a mental deficiency. But the parents decide to keep their son, to allow him a life with dignity and to support him as best as possible. And their devotion bears fruit...

Two men being questioned in a police station on Christmas Eve both confess to the murder of a cop. With both stories seeming plausible, an investigator is called in to determine which suspect is telling the truth - and why the other one is lying. Crime drama, starring James Earl Jones and Jason Bateman.

27 year old surgical resident, Kendal Lawrence is living and working in Brooklyn, New York. She is abducted, on route to meeting her same sex partner, Lauren Stevens and their mutual friend, female police officer, Maria Rossetti. The question of terrorism arises several times throughout the story, with an unexpected medical twist, to the plot. The FBI and the New York Police department work closely together, to determine the reason for the abduction. Sensing a lack of interest, on the part of the police authorities, because of her sexual orientation and her partner's Middle eastern heritage, Lauren decides to launch her own investigation. When you least expect it, your life can take a detour that may in fact, change your world forever.

Life Goes On is a television series that aired on ABC from September 12, 1989, to May 23, 1993. The show centers on the Thatcher family living in suburban Chicago: Drew, his wife Elizabeth, and their children Paige, Rebecca, and Charles, who is known as Corky. Life Goes On was the first television series to have a major character with Down syndrome.

Patrick Jane, a former celebrity psychic medium, uses his razor sharp skills of observation and expertise at "reading" people to solve serious crimes with the California Bureau of Investigation.

Silent Witness is a British crime thriller series focusing on a team of forensic pathology experts and their investigations into various crimes.

No Hiding Place is a British television series that was produced at Wembley Studios by Associated-Rediffusion for the ITV network between 16 September 1959 and 22 June 1967. It was the sequel to the series Murder Bag and Crime Sheet, all starring Raymond Francis as Detective Superintendent, later Detective Chief Superintendent Tom Lockhart.

Born This Way follows a group of young adults with Down syndrome as they pursue their dreams and explore their friendships, romantic relationships, and work.

Dex Parios is a strong, assertive, and unapologetically sharp-witted Army veteran working as a P.I. in Portland, Oregon. With a complicated personal history and only herself to rely on, she solves other people’s messes with a blind eye toward her own.

A detective in a small Pennsylvania town investigates a local murder while trying to keep her life from falling apart.

Series re-examining the evidence from British au pair Louise Woodward's murder trial 25 years ago. Includes unprecedented access to witnesses, the defence team, the prosecution and members of the jury who decided her fate.