Best movies & TV Shows like The Hot Zone

The headlines you remember, the ending you don't.

A unique, carefully handpicked, selection of the best movies like The Hot Zone Starring Daniel Dae Kim, Tony Goldwyn, Dylan Baker, Ian Colletti, and more. If you liked The Hot Zone then you may also like: 28 Days Later, 28 Weeks Later, Yellow Jack, The Zombie Diaries, The Zombie Diaries 2 and many more popular movies featured on this list. You can further filter the list even more or get a random selection from the list of similar movies, to make your selection even easier.

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In this anthology series, heroic scientists risk all to deal with deadly outbreaks.

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28 Days Later

Twenty-eight days after a killer virus was accidentally unleashed from a British research facility, a small group of London survivors are caught in a desperate struggle to protect themselves from the infected. Carried by animals and humans, the virus turns those it infects into homicidal maniacs -- and it's absolutely impossible to contain.

28 Weeks Later

The inhabitants of the British Isles have lost their battle against the onslaught of disease, as the deadly rage virus has killed every citizen there. Six months later, a group of Americans dare to set foot on the isles, convinced the danger has come and gone. But it soon becomes all too clear that the scourge continues to live, waiting to pounce on its next victims.

Yellow Jack

A fairly accurate historical account of Walter Reed's search for the cause of "Yellow Jack" or Yellow Fever and those who risked their lives in the pursuit.

The Zombie Diaries

In the early part of the 21st Century, an unknown virus began spreading among the populous. Within weeks it had engulfed the entire planet, from the smallest communities to the greatest cities. Upon the death of its host, the virus would reanimate the corpse until it was no longer able to support itself. Soon the planet was infested with a new threat - the undead. So begins our journey into the dystopian world of the zombie diaries.

The Zombie Diaries 2

Three months have passed since a viral outbreak wiped out 99.9% of the world's population, turning its victims into flesh-eating living dead. In the UK, a surviving band of soldiers and civilians have taken refuge at a rural military barracks. Life in this new world is tough and brutal, but hope appears when a high level communication is received from a military base on the coast, telling of sanctuary elsewhere in Europe... But just as salvation appears to be in reach, the base suffers an overwhelming defeat at the hands of the living dead! The surviving handful of troops and civilians must now make their way to the coast to uncover the truth behind the message. Their perilous journey takes them across a now treacherous, death-ravaged landscape, where the living dead are vast in number and wandering bandits impose their own malicious sense of law and order. What follows is a journey into hell and a desperate battle against all odds for the very survival of the human race

Operation Delta Force

A team of military experts and scientists go after a terrorist group that has seized a deadly virus and is threatening to release it.

Outbreak

A deadly airborne virus finds its way into the USA and starts killing off people at an epidemic rate. Col. Sam Daniels' job is to stop the virus spreading from a small town, which must be quarantined, and to prevent an over reaction by the White House.

Quarantine

A television reporter and her cameraman are trapped inside a building quarantined by the CDC after the outbreak of a mysterious virus which turns humans into bloodthirsty killers.

Jane

Drawing from never-before-seen footage that has been tucked away in the National Geographic archives, director Brett Morgen tells the story of Jane Goodall, a woman whose chimpanzee research revolutionized our understanding of the natural world.

Cabin Fever: Patient Zero

A group of friends head to a deserted Caribbean island for a surprise overnight bachelor party only to discover that the island isn't deserted. It's actually the home to a secret medical facility. Not only that, there's something wrong with the water surrounding the island...

A Cold Night's Death

Scientists Culp and Wallach suspect that there is someone other than their research primates inhabiting their polar station.

Contagion

As an epidemic of a lethal airborne virus - that kills within days - rapidly grows, the worldwide medical community races to find a cure and control the panic that spreads faster than the virus itself.

The Satan Bug

A US government germ warfare lab has had an accident. The first theory is that one of the germs has been released and killed several scientists. The big fear is that a more virulent strain, named The Satan Bug because all life can be killed off by it should it escape, may have been stolen.

Pandemic

After a virus of epic proportions overwhelms the planet—with more infected than uninfected—humanity is losing its grip on survival and its only hope is finding a cure and keeping the infected contained. Lauren, a doctor, arrives in Los Angeles with her crack team to lead the hunt for uncontaminated civilian survivors, but nothing can prepare them for the blood-soaked mayhem they witness as they head into the Californian streets where everything is considered a trap.

The Crazies

Citizens of a small town are infected by a biological weapon that causes its victims to become violently insane. As uninfected citizens struggle to survive, the military readies its own response.

Night Shadows

When two brothers, Josh and Mike, go to a small southern town for a vacation, they find most of the residents either dead or missing. When Mike himself goes missing, Josh teams up with the local sheriff and an attractive school teacher to find him until Josh discovers that the whole town and most of it's people have been infected by a form of toxic waste, and they have all turned into toxic vampires whom prowl the streets at night for human blood!

Day of the Dead

When a small Colorado town is overrun by the flesh hungry dead, a small group of survivors try to escape in a last ditch effort to stay alive.

Doomsday

The lethal Reaper virus spreads throughout Britain—infecting millions and killing hundreds of thousands. Authorities brutally and successfully quarantine the country but, three decades later, the virus resurfaces in a major city. An elite group of specialists is urgently dispatched into the still-quarantined country to retrieve a cure by any means necessary. Shut off from the rest of the world, the unit must battle through a landscape that has become a waking nightmare.

Fauci

Exclusive access into the career and life of the public servant who has advised seven U.S. presidents beginning with the AIDS pandemic in the 1980s and through SARS, Ebola and COVID-19.

The Directive

In the aftermath of an incurable virus spread, a robot seeking to eradicate humanity deceptively guides a Red Cross survivor to sanctuary with the false hope of his family awaiting in Safe Zone 57.

Pandemic

A slow-paced, action thriller about a virus that strikes a New Mexico county and the local veterinarian who gets caught in the middle.

Stigma

A black doctor ex-convict returns to the all-white town he knows as home and discovers a deadly disease threatening the citizens. He must fight prejudice and time if he is to save the town.

What About ME?

Inside the dramatic search for a cure to ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome). 17 million people around the world suffer from what ME/CFS has been known as a mystery illness, delegated to the psychological realm, until now. A scientist in the only neuro immune institute in the world may have come up with the answer. An important human drama, plays out on the quest for the truth.

The Survivalist

A year and a half after the fall of civilization from a virus outbreak, a former FBI agent is forced to protect a young woman, who is immune to the disease, from a dangerous gang hunting her led by a psychopath who believes he’s going to use her to save the world.

Hidden

A family takes refuge in a fallout shelter to avoid a dangerous outbreak.

The Plague

In a city in South America an outbreak of bubonic plague occurs. While people try to flee and the military close the city, an idealistic doctor decides to stay and help the sick. In the ever-changing circumstances, he puts up a brave fight, being helped by others but also involving them without being able to control the situation.

The Thaw

At a remote Arctic research station, four ecology students discover the real horror of global warming is not the melting ice, but what's frozen within it. A prehistoric parasite is released from the carcass of a Woolly Mammoth upon the unsuspecting students who are forced to quarantine and make necessary sacrifices, or risk infecting the rest of the world.

Trench 11

In the final days of WWI a shell-shocked soldier must lead a mission deep beneath the trenches to stop a German plot that could turn the tide of the war.

Patient Zero

After an unprecedented global pandemic has turned the majority of humankind into violent infected beings, Morgan, a man gifted with the ability to speak the infected's new language, leads the last survivors on a hunt for patient zero and a cure.

Quarantine

In a futuristic society being decimated by plague, a fascist movement seizes power and quarantines not only the plague victims, but anyone related to them. Rebels trying to assassinate a particularly reactionary senator stumble onto a computer programmer trying to track and eradicate the disease.

And the Band Played On

The story of the discovery of the AIDS epidemic and the political infighting of the scientific community hampering the early fight with it.

Mulberry Street

A deadly infection breaks out in Manhattan, causing humans to devolve into blood-thirsty rat creatures. Six recently evicted tenants must survive the night and protect their downtown apartment building as the city quickly spirals out of control.

Growth

In 1989, a breakthrough in "advanced parasitic research" on Cuttyhunk Island gave scientists a jump in human evolution. Initial tests proved promising, as subjects experienced heightened physical and mental strength and awareness. But - something in the experiment went horribly wrong, and the island mysteriously lost three quarters of its population.

Virus Shark

A shark bite spreads a virus across the globe, turning the world upside down. Deep below the ocean, a group of researchers race against time to find a cure. Something has infected the lab technicians and it’s a race against time to reach the surface with an antidote before they are all killed by themselves and the sharks lurking inside the test pool and outside in the ocean.

The Anthrax Attacks: In the Shadow of 9/11

Days after 9/11, letters containing fatal anthrax spores spark panic and tragedy in the US. This documentary follows the subsequent FBI investigation.

Jericho Fever

A group of terrorists bomb peace negotiations in Mexico. One of the terrorists contracts a fever disease during the attack. The terrorists flee across the border to the US and while they are in the process of crossing the border they committ a murder. The sick terrorist infects a large number of people in New Mexico, and the patients start dying as the doctors are unable to cure the disease. A female doctor from the Centers for Disease Control arrives in New Mexico. Together with an FBI agent she starts to search for the terrorists. But there are also others who are looking for the terrorists...

Absolon

In the near future, a virus has infected everyone on the planet, and Absolon is a drug that everyone must take to stay alive. One corporation controls the drug. Murchison is the leader of this firm. A scientist who was researching the virus is found murdered, and Norman Scott is the policeman who investigates the crime.

Dark Island

After losing contact with its researchers on a remote island, a military corporation hires a group of scientists and soldiers to find out what went wrong. But when they arrive, the team quickly discovers that the weapons testing performed on the island has unleashed and powerful and deadly entity that will stop at nothing to destroy them all.

Contagion

In the 21st Century, terrorists have developed a new way to strike: disease. Not only have they created a deadly Level Four Ebola virus, their first victim is the President of the United States. The virus is particularly contagious and is spreading. If a cure cannot be found, the only chance for saving the world from epidemic is for the army to destroy the hospital and the town where the victims, including the President, are currently contained. The clock is ticking. As doctors search for a cure the military seeks to annihilate them all in a race to stop the deadly path of the contagion. Can the spread be stopped before its too late?

Anthrax

When cattle mysteriously start dying of anthrax in a small Alberta ranching community, an RCMP officer tries to keep the peace as ranchers lay the blame on a local agricultural research center. A reporter encourages the angry ranchers - led by the Mountie's mother-in-law - to stage a sit-in at the research center. When an eccentric old rancher dies after being exposed to a deadly strain of anthrax, the protesters are quarantined. No one notices that the reporter has disappeared - along with several vials of the deadly bacteria. The RCMP officer begins his own investigation, gleaning information from a U.S. government agent. He finds himself racing against time to recover the stolen anthrax.

Carriers

A military woman and a worried mother travel overseas and to New Mexico to investigate a deadly virus.

Fringe

FBI Special Agent Olivia Dunham, brilliant but formerly institutionalized scientist Walter Bishop and his scheming, reluctant son Peter uncover a deadly mystery involving a series of unbelievable events and realize they may be a part of a larger, more disturbing pattern that blurs the line between science fiction and technology.

Medical Investigation

Medical Investigation was an American medical drama television series that began September 9, 2004, on NBC. It ran for 20 one-hour episodes before being cancelled in 2005. The series was co-produced by Paramount Network Television and NBC Universal Television Studio The former controls North American distribution rights, while the latter distributes outside North America. The series featured the cases of an elite team of medical experts of the National Institutes of Health who investigate unusual public-health crises, such as sudden outbreaks of serious and mysterious diseases. In actuality, medical investigative duties in the United States are normally the responsibility of the Centers for Disease Control and Prevention and local health departments, while the NIH is primarily a disease-research and -theory organization. The series existed in the same television universe as Third Watch and, by extension ER. A special two-part crossover event aired on February 18, 2005, establishing the television-universe connection by featuring the Third Watch and Medical Investigation teams working together in MI's Episode 17: "Half Life" and Third Watch's Episode 16 of the sixth season: "In the Family Way". The story was about a series of Marburg virus cases in New York.

The Burning Zone

The Burning Zone is a television drama broadcast on the UPN network as part of its 1996–97 lineup. It ran for 19 episodes. The series was rerun on SciFi Channel in the mid-to-late 1990s. The Burning Zone featured a team of American agents who could be almost instantly dispatched almost anywhere in the world to fight biological warfare and naturally occurring biohazards. The series is believed to be cashing in on the success of the New York Times bestseller The Hot Zone, which spawned biological disaster movies like Outbreak. There was a villainous organization known as "The Dawn" that was responsible for some of the threats the team faced. The members of "The Dawn" were shadowy and never fully exposed but their goals and aims were clear: To allow disease and pestilence of a biological nature restore the Earth by rendering extinct the most virulent pestilence of all—mankind.

Helix

Helix is an intense thriller about a team of scientists from the Centers for Disease Control who travel to a high-tech research facility in the Arctic to investigate a possible disease outbreak, only to find themselves pulled into a terrifying life-and-death struggle that holds the key to mankind's salvation...or total annihilation.

Our Girl

Drama following the extraordinary adventures of female medics in the British Army.

Containment

An epidemic breaks out in Atlanta leaving the large city quarantined and those stuck on the inside fighting for their lives. This is the story of loved ones torn apart, and how the society that grows inside the quarantine reveals both the devolution of humanity and the birth of unlikely heroes.

Swamp Thing

CDC researcher Abby Arcane investigates what seems to be a deadly swamp-born virus in a small town in Louisiana but she soon discovers that the swamp holds mystical and terrifying secrets. When unexplainable and chilling horrors emerge from the murky marsh, no one is safe.

Outbreak

A dangerous virus appears in a group of homeless people, causing a risk of outbreak. How long will it take Anne-Marie Leclerc, director of the Emergency Public Health Laboratory, to realize that an actual epidemic is starting to take shape?

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